Celtic gave their chances of reaching the last 32 a boost by beating Ferencvaros 3-2 in Hungary, while Rangers also have it all to play for in the final two games after coming from behind to draw 1-1 away to Brondby.
West Ham are on the brink of guaranteeing top spot in Group H which will book their place in the last 16, but needed Said Benrahma to score twice in Belgium to preserve their unbeaten record in Europe.
In the 1 000th game of his managerial career, David Moyes took the opportunity to rest a number of his key players ahead of Liverpool's visit to the London Stadium on Sunday and paid the price with a slow start as Joseph Paintsil opened the scoring for Genk after just four minutes.
The introduction of Soucek, Pablo Fornals and Jarrod Bowen after the break helped turn the game around.
Benrahma rounded off a brilliant team move to equalise before using his individual skill to wriggle free of the Genk defence and fire powerfully in at the near post.
However, the visitors dropped points for the first time in the group when Soucek's diving header flew into his own net three minutes from time.
"It's a moment I'll really remember because the game will always be remembered for Tomas Soucek's own goal!" Moyes said on his personal landmark.
"But overall I am thrilled to reach a thousand games. It is a great achievement."
LEICESTER PAY PENALTY
Leicester remain third in Group C after Jamie Vardy missed a second-half penalty at the King Power.
Victor Moses headed the Russians in front before Daniel Amartey quickly levelled.
Vardy's spot-kick was saved by Aleksandr Selikhov with 15 minutes remaining.
Serie A leaders Napoli now top the group after thrashing Legia Warsaw 4-1 to move onto seven points with the Poles on six and Leicester on five.
Celtic closed to within a point of Real Betis in Group G thanks to goals from Kyogo Furuhashi, Jota and Liel Abada in Budapest.
Betis were thrashed 4-0 by Leverkusen with Moussa Diaby scoring twice for the Germans.
Leverkusen need just one point from their remaining two games to guarantee top spot and a place in the last 16.
Lyon are already into the last 16 as a 3-0 win over Sparta Prague won Group A.
Sparta and Rangers are level on four points, but the Czechs have the advantage on head-to-head record ahead of the meeting between the sides at Ibrox on November 25.
Ianis Hagi came off the bench to salvage a point for the Scottish champions in Copenhagen after they fell behind to Leon Balogun's own goal.
A four-goal thriller that ended 2-2 between Marseille and Lazio left Group E as it was at the start of the evening as Galatasaray were held 1-1 by Lokomotiv Moscow.
The Turkish giants lead the section on eight points, three clear of Lazio with Marseille one further back.
Monaco maintain a two-point lead over LaLiga leaders Real Sociedad after both games in Group B ended in draws.
Sociedad could only manage a 1-1 draw at home to Sturm Graz to give PSV Eindhoven hope of qualifying as they drew 0-0 in the Principality. (AFP)

Everyone expects Spain to beat us, says Belgium coach
Okoye backs France to win World Cup
Joshua, Fury opponents vow to ruin mega-fight plans
C’wealth Games: Olopade targets swimming, judo breakthrough
Teen girl dies celebrating France’s World Cup win
Balogun apologises to fans after US W’Cup exit
Eaglets suffer second defeat in China tourney
Alalshikh sets condition for Joshua, Fury Wembley fight
France urges calm during World Cup game against MoroccoFrance urges calm during World Cup game against Morocco
2026 FIFA WORLD CUP FINALS: Unprecedented Controversies Simmer as Stakeholders Brand FIFA 'An Absolute Disgrace'
Boniface salutes Neymar, Ronaldo after World Cup exits
Durodola gets 45th KO win at National Stadium
Rangers International going, going . . . (63,944 views)
Amaju Pinnick: A cat with nine lives (55,281 views)
Second Term: Amaju Pinnick, Other NFF Heavyweights Home to Roost •How Pinnick Broke the Jinx (53,190 views)
Current issues in Nigerian sports: Matters arising (52,800 views)
Sports Development: Zenith Bank on the zenith (52,685 views)
Missing $150,000 IAAF Grant: Solomon Dalung’s Hide and Seek game (52,552 views)
Gov. Abdullahi Ganduje’s solid footprints, commitment to sports development in Kano State (52,441 views)
NFF Presidency: Pinnick, Maigari, Ogunjobi, Okoye in Battle for Supremacy (51,960 views)
Olopade, BET9A wave of revolution in NNL (51,176 views)
Commonwealth Games 2018: Shame of Muhammadu Buhari, Solomon Dalung (49,644 views)
Ibrahimovic’s Man U exit: Whose decision is it? And in whose interest? (48,122 views)
John Mikel Obi: Segun Odegbami’s Outrageous Call! (47,511 views)